You can configure different SMTP profiles to send emails from the system.
Notification profiles are used by all functionality introduced after Sitefinity CMS 5.0. For all features that use email setting and are developed before Sitefinity CMS 5.0, you must also configure the SMTP settings. For more information, see Administration: Configure SMTP settings.
NOTE: Using different notification profiles, you can configure more then one SMTP client.
To do this, perform the following:
In order to prevent flooding of the target SMTP server, you can send notifications on batches with a pause interval between them.
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